Cestonex-N is anthelmintic Niclosamide Veterinary Oral Powder is active against tapeworms and intestinal flukes such as paramphistomum in ruminants.
Cestonex-N inhibits phosphorylation in the mitochondria of cestodes. Both in vitro and in vivo, the scolex and Proximal segments are destroyed or dismantled on contact with the drug. The loosened scolex may be digested in the intestine; hence, it may be impossible to identify the scolex in the feces. Cestonex-N is taenicidal in action and eliminates not only the segments but also scolex.
Cestonex-N activity against the worms appears to be due to inhibition of mitochondrial oxidative phosphorylation; anaerobic ATP production is also affected.
The cestocidal activity of Cestonex-N is due to the inhibition of absorption of glucose by the tapeworm and to the uncoupling of the oxidative phosphorylation process in the mitochondria of cestodes. The accumulated lactic acid resulting from the blocking of Kerb's cycle kills the worms.
Indications:
Cestonex-N is indicated in both tapeworm infestation of Livestock, Poultry, Dogs and Cats and also in immature
paramphistomiasis (Amphistomiasis) of Cattle, Sheep and Goats.
Composition:
Each gram contains:
Niclosamide I.P. : 750 mg
Administation and dosage:
Cestonex-N dispersible powder may be administered as a drench, in feed or as such.
Against Tapeworms:
| Cattle and Horses | 1 gm for 15 kg body weight |
|---|---|
| Sheep and Goats | 1 gm for 10 kg body weight |
| Dogs and Cats | 1 gm for 7.5 kg body weight (130 mg per kg body weight) |
| Poultry | 1 gm for 5 adult birds (Approx. 175 mg per kg body Weight) |
Against Amphistomes:
Cattle, Sheep & Goats: Higher dosage at the rate of 120 mg/kg body weight is recommended. Therefore 3 gm of Cestonex-N may be given to an animal weighing 25 kg.
Presentation: 50 gm.,100 gm. and 500 gm.